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The use of Fmoc chemistry for cover of your alpha amino group is becoming the preferred system for the majority of modern day stable and Alternative section peptide synthetic processes. Fmoc has also been proven for being much more dependable and create higher good quality peptides than Boc chemistr
In the displacement step (a classical SN2 reaction), an amine displaces the halide to form the N-substituted glycine residue. The submonomer technique lets the use of any commercially accessible or synthetically accessible amine with good possible for combinatorial chemistry.
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